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Michel Lebel et al.
AGEING RESEARCH REVIEWS (2018)
Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels
Jing-Xiang Wu et al.
PROTEIN & CELL (2018)
Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model
Shuyan Wang et al.
CELL DEATH & DISEASE (2018)
The Caenorhabditis elegans WRN helicase promotes double-strand DNA break repair by mediating end resection and checkpoint activation
Jin-Sun Ryu et al.
FEBS LETTERS (2017)
NAD+ in Aging: Molecular Mechanisms and Translational Implications
Evandro F. Fang et al.
TRENDS IN MOLECULAR MEDICINE (2017)
Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions
Junko Oshima et al.
AGEING RESEARCH REVIEWS (2017)
Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review
Jin-Sun Ryu et al.
GERONTOLOGY (2016)
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Evandro Fei Fang et al.
CELL METABOLISM (2016)
Absence of premature senescence in Werner's syndrome keratinocytes
Badr Ibrahim et al.
EXPERIMENTAL GERONTOLOGY (2016)
Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
Navdeep S. Chandel et al.
NATURE CELL BIOLOGY (2016)
Nuclear DNA damage signalling to mitochondria in ageing
Evandro Fei Fang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
WRN regulates pathway choice between classical and alternative non-homologous end joining
Raghavendra A. Shamanna et al.
Nature Communications (2016)
Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities
Jean-Philippe Gagne et al.
ONCOTARGET (2016)
Vitamin C alleviates aging defects in a stem cell model for Werner syndrome
Ying Li et al.
PROTEIN & CELL (2016)
SIRT7, the UPR and HSC ageing
Katharine H. Wrighton
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Weiqi Zhang et al.
SCIENCE (2015)
Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming
Akira Shimamoto et al.
FRONTIERS IN GENETICS (2015)
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice
Lucie Aumailley et al.
PLOS ONE (2015)
Multiplex cytokine analysis of Werner syndrome
Makoto Goto et al.
INTRACTABLE & RARE DISEASES RESEARCH (2015)
Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells
Baomin Li et al.
AGING CELL (2014)
Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts
Bidisha Saha et al.
AGING CELL (2014)
Human RecQ Helicases in DNA Repair, Recombination, and Replication
Deborah L. Croteau et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)
Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span
Alexandra Dallaire et al.
BMC GENOMICS (2014)
Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
Evandro Fei Fang et al.
CELL (2014)
A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
Morten Scheibye-Knudsen et al.
CELL METABOLISM (2014)
The Drosophila Werner Exonuclease Participates in an Exonuclease-Independent Response to Replication Stress
Elyse Bolterstein et al.
GENETICS (2014)
Search and Insights into Novel Genetic Alterations Leading to Classical and Atypical Werner Syndrome
Junko Oshima et al.
GERONTOLOGY (2014)
Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model
Victoria C. Cogger et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture
Akira Shimamoto et al.
PLOS ONE (2014)
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice
H. Lu et al.
CELL DEATH & DISEASE (2014)
Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging
Hoi-Hung Cheung et al.
STEM CELL REPORTS (2014)
Genomics of human health and aging
Alexander M. Kulminski et al.
AGE (2013)
The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites
Penelope A. Mason et al.
AGE (2013)
Meta-analysis of genetic variants associated with human exceptional longevity
Paola Sebastiani et al.
AGING-US (2013)
Functional deficit associated with a missense Werner syndrome mutation
Takashi Tadokoro et al.
DNA REPAIR (2013)
The non-synonymous polymorphism at position 114 of the WRN protein affects cholesterol efflux in vitro and correlates with cholesterol levels in vivo
Julien Berube et al.
EXPERIMENTAL GERONTOLOGY (2013)
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
D. T. Chen et al.
MOLECULAR PSYCHIATRY (2013)
Hydrogen sulfide restores a normal morphological phenotype in Werner syndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway
F. Talaei et al.
PHARMACOLOGICAL RESEARCH (2013)
Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging
Alexandra Dallaire et al.
AGING-US (2012)
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP
Simon Mead et al.
HUMAN MOLECULAR GENETICS (2012)
The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures
Ashwini Kamath-Loeb et al.
PLOS ONE (2012)
Genetic Signatures of Exceptional Longevity in Humans
Paola Sebastiani et al.
PLOS ONE (2012)
Accelerated in vivo epidermal telomere loss in Werner syndrome
Naoshi Ishikawa et al.
AGING-US (2011)
The Werner and Bloom Syndrome Proteins Help Resolve Replication Blockage by Converting (Regressed) Holliday Junctions to Functional Replication Forks
Amrita Machwe et al.
BIOCHEMISTRY (2011)
Four faces of cellular senescence
Francis Rodier et al.
JOURNAL OF CELL BIOLOGY (2011)
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
Francis Rodier et al.
JOURNAL OF CELL SCIENCE (2011)
Vitamin C restores healthy aging in a mouse model for Werner syndrome
Laurent Massip et al.
FASEB JOURNAL (2010)
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations
Katrin Friedrich et al.
HUMAN GENETICS (2010)
BIGUANIDE, BUT NOT THIAZOLIDINEDIONE, IMPROVED INSULIN RESISTANCE IN WERNER SYNDROME
Hisafumi Yasuda et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2010)
The Caenorhabditis elegans Werner Syndrome Protein Functions Upstream of ATR and ATM in Response to DNA Replication Inhibition and Double-Strand DNA Breaks
Se-Jin Lee et al.
PLOS GENETICS (2010)
DmWRNexo is a 3'aEuro5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease
Ivan Boubriak et al.
BIOGERONTOLOGY (2009)
Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity
Robert D. C. Saunders et al.
AGING CELL (2008)
Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans
Moonjung Hyun et al.
BIOCHEMISTRY (2008)
Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan
Robert Nakayama et al.
CANCER SCIENCE (2008)
Extension of the life span in patients with Werner syndrome
Koutaro Yokote et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2008)
Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions
Jeanine A. Harrigan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1
Aditi Das et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Role for the Werner syndrome protein in the promotion of tumor cell growth
Patricia L. Opresko et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2007)
Telomere dysfunction as a cause of genomic instability in Werner syndrome
Laure Crabbe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The role of WRN in DNA repair is affected by post-translational modifications
Rika Kusumoto et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2007)
Werner Syndrome and Mutations of the WRN and LMNA Genes in France
Nancy A. Uhrhammer et al.
HUMAN MUTATION (2006)
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
Min Shen et al.
HUMAN GENETICS (2006)
The spectrum of WRN mutations in Werner syndrome patients
Shurong Huang et al.
HUMAN MUTATION (2006)
Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue
L Massip et al.
EXPERIMENTAL GERONTOLOGY (2006)
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links
Wen-Hsing Cheng et al.
NUCLEIC ACIDS RESEARCH (2006)
Werner protein protects nonproliferating cells from oxidative DNA damage
AM Szekely et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Deficient DNA repair in the human progeroid disorder, Werner syndrome
VA Bohr
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus
M Hirai et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2005)
A mouse model of Werner Syndrome: what can it tell us about aging and cancer?
S Chang
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)
Regulation of WRN helicase activity in human base excision repair
B Ahn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
L Crabbe et al.
SCIENCE (2004)
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
S Chang et al.
NATURE GENETICS (2004)
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
PL Opresko et al.
MOLECULAR CELL (2004)
A Werner syndrome protein homolog affects C-elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint
SJ Lee et al.
DEVELOPMENT (2004)
Dysadipocytokinemia in Werner syndrome and its recovery by treatment with pioglitazone
K Yokote et al.
DIABETES CARE (2004)
LMNA mutations in atypical Werner's syndrome
LS Chen et al.
LANCET (2003)
Werner syndrome protein limits MYC-induced cellular senescence
C Grandori et al.
GENES & DEVELOPMENT (2003)
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
M Lebel et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA
AM Rodríguez-López et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2003)
Asymmetry of DNA replication fork progression in Werner's syndrome
AM Rodríguez-López et al.
AGING CELL (2002)
Roles of the Werner syndrome protein in pathways required for maintenance of genome stability
RM Brosh et al.
EXPERIMENTAL GERONTOLOGY (2002)
Pathways defective in the human premature aging disease Werner syndrome
VA Bohr et al.
BIOGERONTOLOGY (2002)
Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle
P Pichierri et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Diverged nuclear localization of Werner helicase in human and mouse cells
T Suzuki et al.
ONCOGENE (2001)
Selective blockage of the 3′→5′ exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA
A Machwe et al.
NUCLEIC ACIDS RESEARCH (2000)
Characterization of the human and mouse WRN 3′→5′ exonuclease
SR Huang et al.
NUCLEIC ACIDS RESEARCH (2000)
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
JC Shen et al.
NUCLEIC ACIDS RESEARCH (2000)
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
FS Wyllie et al.
NATURE GENETICS (2000)