期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1862, 期 3, 页码 253-269出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2018.11.009
关键词
RNA modification; Epitranscriptome; tRNA; rRNA; mRNA; Sn/snoRNA; Ribose methylation
资金
- ANR-DFG grant [HTRNA-Mod ANR-13-ISV8-0001]
- Lorraine Region (France)
Methylation of riboses at 2'-OH group is one of the most common RNA modifications found in number of cellular RNAs from almost any species which belong to all three life domains. This modification was extensively studied for decades in rRNAs and tRNAs, but recent data revealed the presence of 2'-O-methyl groups also in low abundant RNAs, like mRNAs. Ribose methylation is formed in RNA by two alternative enzymatic mechanisms: either by stand-alone protein enzymes or by complex assembly of proteins associated with snoRNA guides (sno(s)RNPs). In that case one catalytic subunit acts at various RNA sites, the specificity is provided by base pairing of the sno(s)RNA guide with the target RNA. In this review we compile available information on 2'-OH ribose methylation in different RNAs, enzymatic machineries involved in their biosynthesis and dynamics, as well as on the physiological functions of these modified residues.
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