期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1862, 期 3, 页码 270-279出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2018.09.011
关键词
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资金
- Medical Research Council Senior Fellowship [MR/K024213/1]
- European Research Council [769080 TCAPS]
- Royal Society Wolfson Research Merit Award [WRM\R1\180008]
- MRC [MR/K024213/1] Funding Source: UKRI
In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5' end of RNA pol II-transcribed RNA. It protects RNA from degradation, recruits complexes involved in RNA processing, export and translation initiation, and marks cellular mRNA as self to avoid recognition by the innate immune system. The mRNA cap can be viewed as a unique mark which selects RNA pol II transcripts for specific processing and translation. Over recent years, examples of regulation of mRNA cap formation have emerged, induced by oncogenes, developmental pathways and during the cell cycle. These signalling pathways regulate the rate and extent of mRNA cap formation, resulting in changes in gene expression, cell physiology and cell function.
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