期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1862, 期 3, 页码 343-355出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2018.12.001
关键词
m(6)A; m(6)A(m); RNA demethylase; FTO; ALKBH5; RNA modification
资金
- Ministry of Education, Youth and Sports of the Czech Republic under the project CEITEC 2020 [LQ1601]
- Ministry of Education, Youth and Sports of the Czech Republic within programme INTER COST [LTC18052]
RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N-6-adenosine methylation (m(6)A) is the most prevalent internal chemical modification identified to date. The m(6)A pathway involves factors called writers, readers and erasers. m(6)A thus offers an interesting concept of dynamic reversible modification with implications in fine-tuning the cellular metabolism. In mammals, FTO and ALKBH5 have been initially identified as m(6)A erasers. Recently, FTO m(6)A specificity has been debated as new reports identify FTO targeting N-6,2'-O-dimethyladenosine (m(6)A(m)). The two adenosine demethylases have diverse roles in the metabolism of mRNAs and their activity is involved in key processes, such as embryogenesis, disease or infection. In this article, we review the current knowledge of their function and mechanisms and discuss the existing contradictions in the field. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.
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