期刊
ATHEROSCLEROSIS
卷 284, 期 -, 页码 121-128出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2018.11.038
关键词
Gut microbiome; Cardiac valve calcification; Coronary artery disease
资金
- National Natural Science Foundation of China [81770386, 81570352]
- Science and Technology Program of Guangzhou [201707020012]
- Science and Technology Program of Guangdong Province [2017A050501019]
- Natural Science Foundation of Guangdong Province [2015A030310441]
- Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University [2015J004]
Background and aims: Although most risk factors for cardiac valve calcification (VC) are similar to those for coronary artery disease (CAD), they differ regarding lesions and clinical symptoms. Recently, increasing evidence suggests that intestinal bacteria play essential roles in cardiovascular disease (CVD). It is plausible that the gut microbiota is linked to the occurrence of different CVDs under similar risk factors. Thus, we aimed to explore the gut microbiomes in patients with VC or CAD and determine their underlying connections. Methods: We collected samples from 119 subjects and performed 16S rRNA gene sequencing to analyze the gut microbiomes in VC and CAD patients and in control volunteers. Results: The gut microbiomes of VC and CAD patients were significantly different in terms of beta-diversity. Bacteria from Veillonella dispar, Bacteroides plebeius and Fusobacterium were enriched in the VC group, while members of Collinsella aerofaciens, Megamonas, Enterococcus, Megasphaera, Dorea and Blautia were decreased. According to the association with dyslipidemia, seven operational taxonomic units (OTUs), including Parabacteroides distasonis, Megamonas, Fusobacterium, Bacteroides sp., Bacteroides plebeius, Lactobacillus and Prevotella copri, were regarded as potential pathogens for CVDs. Additionally, Prevotella copri might be a keystone of CVDs, especially in VC patients, while Collinsella aerofaciens is a possible keystone of CAD, based on the multicorrelations of these bacteria with other OTUs in microbial communities. Conclusions: Patients with VC and CAD suffer from different gut microbial dysbiosis. The gut microbiomes are associated with the clinical characteristics in these diseases and might be potential therapeutic targets.
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