期刊
ATHEROSCLEROSIS
卷 280, 期 -, 页码 85-91出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2018.11.011
关键词
Prevention; LDL-Hypercholesterolemia; Children; Population screening
资金
- Juvenile Diabetes Research Foundation [2-SRA-2016-243-Q-R]
- Liona M. and Harry B. Helmsley Charitable Trust
- Sanofi-Aventis Deutschland GmbH
- Freunde AUF DER BULT e.V.
- Kind und Diabetes e.V.
Background and aims: Lipid disorders are often detected very late, particularly in affected young children. We evaluated the feasibility of a screening for LDL-hypercholesterolemia (highLDL) among toddlers and preschoolers. Methods: Population-based screening has been offered to all children (2-6 years) living in the State of Lower Saxony, Germany, with capillary blood sampling for detection of elevated LDL-cholesterol (LDL-C >= 135 mg/dL). Positive results were confirmed by a second measurement. Follow-up in specialized centers, including disease specific counselling and extended diagnostics, as well as evaluation of psychological distress of the parents, is carried out longitudinally. Results: Up to March 2018, 5656 children have participated in the screening program. 5069/5656 children have completed the screening for highLDL (52.0% boys; median age: 4.0 years [Interquartile range, IQR 3.0-5.1]; mother age: 35 years [IQR 31-38]; father's age: 37 years; [IQR 33-42]). HighLDL was identified in 112 children (2.2%; 40.2% boys; LDL-C 157.6 +/- 29.5 mg/dL, mean +/- SD). In the total cohort, parents stated in 40.9% of the cases a positive family history for hyperlipidemia and in 29.9% a premature cardiovascular event. Children with highLDL had more often both risk factors in their family history; however, in 37% of them none of these factors were reported. Conclusions: The first results of the screening program showed its feasibility and revealed high prevalence of highLDL in the general population. Furthermore, a large proportion of families of affected children were not aware about their lipid disorders.
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