期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 41, 期 11, 页码 1033-1050出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-018-1083-6
关键词
Natural compounds; Toxicity; Mechanisms; Radioprotectors
资金
- National Research Foundation of Korea - Korean government (Ministry of Science and ICT) [2017R1A2B2002327, 2017M2A2A702019560, 2018R1A5A2025286]
- National Research Foundation of Korea [2017R1A2B2002327] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Radiotherapy is one of the most efficient ways to treat cancer. However, deleterious effects, such as acute and chronic toxicities that reduce the quality of life, may result. Naturally occurring compounds have been shown to be non-toxic over wide dose ranges and are inexpensive and effective. Additionally, pharmacological strategies have been developed that use radioprotectors to inhibit radiation-induced toxicities. Currently available radioprotectors have several limitations, including toxicity. In this review, we present the mechanisms of proven radioprotectors, ranging from free radical scavenging (the best-known mechanism of radioprotection) to molecular-based radioprotection (e.g., upregulating expression of heat shock proteins). Finally, we discuss naturally occurring compounds with radioprotective properties in the context of these mechanisms.
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