期刊
BIOCHEMICAL JOURNAL
卷 468, 期 -, 页码 17-24出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20141506
关键词
non-enzyme; non-peptidase homologue; protease homologue; pseudoenzyme; pseudoprotease
资金
- National Health and Medical Research Council [1054968]
- Australian Research Council [FT130101875]
- Australian Research Council [FT130101875] Funding Source: Australian Research Council
Catalytically inactive enzymes (also known as pseudoproteases, protease homologues or paralogues, non-peptidase homologues, non-enzymes and pseudoenzymes) have traditionally been hypothesized to act as regulators of their active homologues. However, those that have been characterized demonstrate that inactive enzymes have an extensive and expanding role in biological processes, including regulation, inhibition and immune modulation. With the emergence of each new genome, more inactive enzymes are being identified, and their abundance and potential as therapeutic targets has been realized. In the light of the growing interest in this emerging field the present review focuses on the classification, structure, function and mechanism of inactive enzymes. Examples of how inactivity is defined, how this is reflected in the structure, functions of inactive enzymes in biological processes and their mode of action are discussed.
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