期刊
APPLIED SURFACE SCIENCE
卷 465, 期 -, 页码 320-331出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2018.09.166
关键词
Laser-scribed carbon paper; Cu network; Flexible biosensors; Glucose; Perspiration
类别
资金
- National Natural Science Foundation of China [61371019]
- Science and Technology Commission of Shanghai Municipality [17DZ1202300, 16DZ2260600]
- Shanghai Technical Trade Solutions Project [16TBT011]
- Key research program of Science and Technology Commission Foundation of Jiangsu Province [BE2015649]
Owing to the high specific surface area and easy accessability to targeting biomolecules, emerging non-noble-metal networks are developed as an ultra-active catalyst for molecular detection. In this work, a facile flexible enzyme-free glucose sensor with superior sensing performance has been successfully constructed by integrating laser-scribed carbon paper (LSCP) with copper network (CN). Remarkably, operation parameters are modeled and optimized by Central Composite Design (CCD) to obtain an optimal conductivity of 4.783 x 10(7) S.m(-1) for CN. Due to the great electronic/ionic pathway between LSCP of ample active sites and CN of excellent conductivity, the disposable biosensor exhibits fast electron transfer kinetics. For glucose detection, LSCP/CN exhibits an excellent sensitivity of 3626.6 mu A mM(-1) cm(-2), a wide linear range from 1 mu M to 7.96 mM, an ultra-low detection limit of 30 nM (S/N = 3) as well as favorable reusability. Satisfactory anti-interference capacity to electro-active oxides and selectivity against carbohydrates studied for concentrations up to normal physiologic levels and higher concentrations are systematically investigated. The applications of glucose determination in human serum and perspiration samples are also successful, with recoveries of 100.8% (+/- 2.28%) and 92.1% (+/- 3.61%), respectively. Experimentally, the current response of the LSCP/CN biosensor is resilient to mechanical deformation with less than 8% decay even after 1000 cycles of 1 mm repeated bending and 180 degrees cyclical folding tests. As such, LSCP/CN can be applicable for flexible, attachable and potentially wearable biosensors to attain real-time physiological monitoring.
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