期刊
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
卷 125, 期 1, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00339-018-2343-5
关键词
-
资金
- National Nature Science Foundation of China [51473076]
- National Key R&D Program of China [2018YFB1105400]
Size-based filtration has been proved an efficient and quick approach to separate circulating tumor cells (CTCs) from other blood cells for cancer diagnosis and therapy monitoring. In this work, we proposed a simple, cost efficient and scalable approach to fabricate microporous polyethylene (PE) membranes for CTC filtration by thermal nanoimprint method. PE was selected as the material for the membrane due to its commercially available films with a thickness as thin as 10 mu m, which is matched well with the size of the micropores for CTCs and critical to a successful nanoimprint with a low and uniform residual layer. A thermal imprint process with a nickel mold was applied to fabricate periodic microporous PE membranes with a pitch of 20 mu m and diameter of 10 mu m. The perforated micropores were obtained by a short time O-2 plasma-etching to remove the imprint residual layer. This PE membrane microfilter achieved 84% average capture efficiency for lung cancer cells spiked in blood samples.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据