期刊
BIOCHEMICAL JOURNAL
卷 465, 期 -, 页码 185-194出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20141078
关键词
induced pluripotent stem cell (iPSC); regenerative therapy; signalling; vascular smooth muscle cell (VSMC)
资金
- National Institutes of Health [1K02HL101990-01, 1R01HL116705-01]
- Connecticut Stem Cell Research Program [12-SCB-YALE-06, 11SCA33, 11SCB18]
- American Heat Association [09SDG2080420]
- Cardiovascular Medical Research and Education Fund
- National Science Foundation [DGE-1122492]
Vascular smooth muscle cells (VSMCs) play a major role in the pathophysiology of cardiovascular diseases. The advent of induced pluripotent stem cell (iPSC) technology and the capability of differentiating into virtually every cell type in the human body make this field a ray of hope for vascular regenerative therapy and understanding of the disease mechanism. In the present review, we first discuss the recent iPSC technology and vascular smooth muscle development from an embryo and then examine different methodologies to derive VSMCs from iPSCs, and their applications in regenerative therapy and disease modelling.
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