期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 63, 期 3, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02273-18
关键词
Klebsiella pneumoniae; ST23; bla(CTX-M-24); high-pathogenicity island; horizontal gene transfer (HGT); mobile genetic elements (MGEs); multidrug-resistant and hypervirulent Klebsiella pneumoniae (MDR-HvKP); virulent plasmid
资金
- National Natural Science Foundation of China (NSFC) [31770870, 31601047, 31570133, 81472012]
Here, we report a multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-HvKP) strain of sequence type 23 (ST23) with a rare hybrid plasmid harboring virulence genes and bla(CTX-M-24), and we analyze the genetic basis for relationship between genotypes and MDR-hypervirulence phenotypes. Further analysis indicates that the hybrid plasmid is formed by IS903D-mediated intermolecular transposition of the bla(CTX-M-24) gene into the virulence plasmid. The emergence of MDR-HvKP strains, especially those carrying drug-resistant virulent plasmids, poses unprecedented threats/challenges to public health. This is a dangerous trend and should be closely monitored.
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