期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 81
卷 81, 期 -, 页码 403-428出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-020518-114640
关键词
cellular metabolism; lung; glycolysis; energy; mitochondria; respiratory disease
类别
资金
- NHLBI NIH HHS [R35 HL135830, R01 HL126737, R01 HL131784] Funding Source: Medline
The lung is often overlooked as a metabolically active organ, yet biochemical studies have long demonstrated that glucose utilization surpasses that of many other organs, including the heart, kidney, and brain. For most cells in the lung, energy consumption is relegated to performing common cellular tasks, like mRNA transcription and protein translation. However, certain lung cell populations engage in more specialized types of energy-consuming behaviors, such as the beating of cilia or the production of surfactant. While many extrapulmonary diseases are now linked to abnormalities in cellular metabolism, the pulmonary community has only recently embraced the concept of metabolic dysfunction as a driver of respiratory pathology. Herein, we provide an overview of the major metabolic pathways in the lung and discuss how cells sense and adapt to low-energy states. Moreover, we review some of the emerging evidence that links alterations in cellular metabolism to the pathobiology of several common respiratory diseases.
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