期刊
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 14
卷 14, 期 -, 页码 211-238出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathmechdis-012418-012827
关键词
microRNAs; biomarkers; cardiovascular disease; hypertension; sepsis; aortic stenosis
类别
资金
- NCATS NIH HHS [UL1 TR001450] Funding Source: Medline
- NHLBI NIH HHS [R01 HL137811, K23 HL135263] Funding Source: Medline
- NIGMS NIH HHS [R01 GM113995] Funding Source: Medline
Cardiovascular diseases exist across all developed countries. Biomarkers that can predict or diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in afflicted individuals. microRNAs are small regulatory RNAs that modulate translation and have been identified as potential fluid-based biomarkers across numerous maladies. We describe the current state of cardiovascular disease biomarkers across a range of diseases, including myocardial infarction, acute coronary syndrome, myocarditis, hypertension, heart failure, heart transplantation, aortic stenosis, diabetic cardiomyopathy, atrial fibrillation, and sepsis. We present the current understanding of microRNAs as possible biomarkers in these categories and where their best opportunities exist to enter clinical practice.
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