期刊
ANNUAL REVIEW OF GENETICS, VOL 52
卷 52, 期 -, 页码 43-63出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120417-031559
关键词
neural crest; collective cell migration; morphogenesis; contact inhibition of locomotion; chemotaxis; confinement
资金
- BBSRC [BB/R00627X/1] Funding Source: UKRI
- Wellcome Trust [084247/Z/07/Z] Funding Source: Wellcome Trust
- Biotechnology and Biological Sciences Research Council [M008517] Funding Source: Medline
- Medical Research Council [M010465] Funding Source: Medline
- Wellcome Trust [084247/Z/07/Z] Funding Source: Medline
Neural crest cells are a transient embryonic cell population that migrate collectively to various locations throughout the embryo to contribute a number of cell types to several organs. After induction, the neural crest delaminates and undergoes an epithelial-to-mesenchymal transition before migrating through intricate yet characteristic paths. The neural crest exhibits a variety of migratory behaviors ranging from sheet-like mass migration in the cephalic regions to chain migration in the trunk. During their journey, neural crest cells rely on a range of signals both from their environment and within the migrating population for navigating through the embryo as a collective. Here we review these interactions and mechanisms, including chemotactic cues of neural crest cells' migration.
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