期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34
卷 34, 期 -, 页码 427-450出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100616-060647
关键词
nephrogenesis; organogenesis; cap mesenchyme; nephron progenitor cell; nephron differentiation; mesenchyme-to-epithelium transition
资金
- NIDDK NIH HHS [R01 DK078161, R24 DK106743] Funding Source: Medline
The nephron is a multifunctional filtration device equipped with an array of sophisticated sensors. For appropriate physiological function in the human and mouse, nephrons must be stereotypically arrayed in large numbers, and this essential structural property that defines the kidney is determined during its fetal development. This review explores the process of nephron determination in the fetal kidney, providing an overview of the foundational literature in the field as well as exploring new developments in this dynamic research area. Mechanisms that ensure that a large number of nephrons can be formed from a small initial number of progenitor cells are central to this process, and the question of how the nephron progenitor cell population balances epithelial differentiation with renewal in the progenitor state is a subject of particular interest. Key growth factor signaling pathways and transcription factor networks are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据