期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 1, 页码 269-272出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812482
关键词
gene therapy; indocyanine green; metal-organic nanostructures; phototherapy; Zn-II-dipicolylamine
资金
- Major State Basic Research Development Program of China [2017YFA0205201, 2018YFA0107301]
- National Natural Science Foundation of China [81422023, 81603015, 81871404, U1705281, U1505221]
- Fundamental Research Funds for the Central Universities [20720160065, 20720150141]
- Program for New Century Excellent Talents in University, China [NCET-13-0502]
We report the rational design of coordination-driven self-assembly metal-organic nanostructures for multifunctional nanotheranostics. Zinc(II) coordination-based nano-formulations capable of loading indocyanine green (ICG) and therapeutic genes were prepared to achieve a fluorescence/photoacoustic imaging-guided combination photo/gene therapy strategy. We showed the enhanced theranostic capability of zinc(II)-dipicolylamine-assisted assembly of ICG, as well as simultaneous targeted gene delivery in an experimental mouse model of cancer. Such a co-assembly strategy provides a facile way to achieve combined therapeutic functions for personalized nanomedicine.
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