期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 7, 页码 2050-2054出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812878
关键词
invivo cross-linking; inflammation; lanthanide; NIR-II bioimaging; ultra-small nanoparticles
资金
- National Key RAMP
- D Program of China [2017YFA0207303]
- National Natural Science Foundation of China [21725502]
- Key Basic Research Program of Science
- Technology Commission of Shanghai Municipality [17JC1400100]
To improve the bioimaging signal-to-noise ratio (SNR), long-term imaging capability, and decrease the potential biotoxicity, an invivo cross-linking strategy was developed by using sub-10nm, glutathione-modified, lanthanide nanoprobes. After administration, the nanoprobes cross-link in response to reactive oxygen species (ROS) at the inflamed area and enable the quick imaging of ROS in the second near-infrared (NIR-II) window. These nanoprobes could be rapidly excreted due to their ultra-small size. This strategy may also be applied to other ultra-small contrast agents for the precise bioimaging by insitu lesion cross-linking.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据