期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 2, 页码 532-536出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201810262
关键词
amination; aromatic substitution; photocatalysis; radical reactions; synthetic methods
资金
- Kwanjeong Educational Foundation
- UCB Biopharma
- Max-Planck-Institut fur Kohlenforschung
(Hetero)arylamines constitute some of the most prevalent functional molecules, especially as pharmaceuticals. However, structurally complex aromatics currently cannot be converted into arylamines, so instead, each product isomer must be assembled through a multistep synthesis from simpler building blocks. Herein, we describe a late-stage aryl C-H amination reaction for the synthesis of complex primary arylamines that other reactions cannot access directly. We show and rationalize through a mechanistic analysis the reasons for the wide substrate scope and the constitutional diversity of the reaction, which gives access to molecules that would not have been readily available otherwise.
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