期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 1, 页码 278-282出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812668
关键词
enzyme mimicry; enzyme-prodrug therapy; glucuronide; nanozymes; prodrugs
资金
- European Research Council Consolidator Grant [ERC-2013-CoG 617336 BTVI]
- Aarhus University Research Foundation [AUFF-E-2016-FLS-9-32]
- Villum Foundation Young Investigator Programme [VKR 023449]
- Danish National Research Foundation (Carbon Dioxide Activation Center) [DNRF 118]
- Australian Research Council [FT140101285, DP170103477]
- RMIT Microscopy and Microanalysis Facility (RMMF)
Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near-exclusively performing redox reactions. We present an unexpected discovery of non-proteinaceous enzymes based on metals, metal oxides, 1D/2D-materials, and non-metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan-glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human metabolites and privileged prodrugs in the field of enzyme-prodrug therapies. Lastly, nanozymes are employed for conversion of glucuronide prodrugs into marketed anti-inflammatory and antibacterial agents, as well as nanozyme prodrug therapy to mediate antibacterial measures.
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