期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 1, 页码 302-306出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811023
关键词
annulation; carbohelicenes; C-H activation; radical reactions; rhodium catalysis
资金
- National NSF of China [21772128, 21432005]
- Fundamental Research Funds for the Central Universities [2012017yjsy108]
Disclosed herein is the merging of C-H activation and radical chemistry, enabling rapid access to a structurally diverse family of fused carbohelicenes through the fusion of alpha-acetylnaphthalenes with alkynes under oxidative conditions. This cascade process exhibits exquisite chemoselectivity and regioselectivity. The reaction pathway was analyzed by intermediate separations, control experiments, radical trapping, EPR, MALDI-TOF-MS, and ESI-HRMS experiments, and shown to involve a C2-H activation/radical reaction/C8-H activation relay.
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