期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 6, 页码 1803-1807出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812426
关键词
C-H functionalization; cobalt; chiral phosphoramidites; palladium; synergistic effects
资金
- MOST (973 project) [2015CB856600]
- NSFC [21831007, 21672002]
- Chinese Academy of Science [XDB20020000]
- Shenzhen STIC [JCYJ20170412150343516]
An unusual hybrid palladium catalyst containing an anionic chiral Co-III complex and a chiral phosphoramidite ligand shows a high capacity for catalyzing asymmetric thioamide-directed C(sp(3))-H arylation and delivers excellent yield and enantioselectivity (up to 99% yield, 99% ee). Significant synergy between the chiral ligand and the anion in terms of stereochemical control was observed. Mechanistic investigations have revealed both the nature of the C-H activation and the origin of the enantioselectivity.
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