期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 51, 页码 16861-16865出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811036
关键词
C-C activation; cyclopropanes; DFT calculations; hydroboration; metal-free synthesis
资金
- Chinese Thousand Youth Talents Plan
- Innovation & Entrepreneurship Talents Plan of Jiangsu Province
- National Science Foundation of the USA [CHE-1361104]
The Brown hydroboration reaction, first reported in 1957, is the addition of B-H across an olefin in an anti-Markovnikov fashion. Here, we solved a long-standing problem on mild 1,3-hydroborations of non-activated cyclopropanes. A three-component system including cyclopropanes, boron halides, and hydrosilanes has been developed for borylative ring-opening of cyclopropanes following the anti-Markovnikov rule, under mild reaction conditions. Density functional theory (M06-2X) calculations show that the preferred pathway involves a cationic boron intermediate which is quenched by hydride transfer from the silane.
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