期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 49, 页码 16194-16199出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811051
关键词
copolymerization; cycloaddition; polymers; sequence determination; synthetic methods
资金
- Boston College
The orthogonal sulfur-fluoride exchange reaction (SuFEx) and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) are employed to synthesize sequence-regulated synthetic polymers. The high efficiency and broad tolerance of SuFEx and CuAAC to diverse chemical functionalities enable the one-pot synthesis of polydispersed sequence-controlled polymers by step-growth copolymerization in high yield and sequence complexity. Furthermore, iterative SuFEx and CuAAC coupling reactions on a solid support, without the need of protecting groups, afford monodispersed sequence-defined oligomers. The use of this orthogonal pair of click reactions provides new opportunities to facilely access sequence-regulated synthetic polymers with a high degree of structural diversity.
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