期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 15, 页码 4948-4952出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201814370
关键词
cofactor recycling; electrocatalysis; ferredoxin NADP(+) reductase; nanoconfinement; nicotinamide
资金
- Biotechnology and Biological Sciences Research Council [BB/P023797/1]
- European Research Council
- BBSRC [BB/P023797/1] Funding Source: UKRI
In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP(+) are cycled rapidly between ferredoxin-NADP(+) reductase and a second enzyme-the pairs being juxtaposed within the 5-100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.
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