期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 25, 页码 8304-8329出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808159
关键词
catalysis; C-H activation; removable directing groups; rhodium
资金
- MEXT [17H06091]
- Grants-in-Aid for Scientific Research [17H06091] Funding Source: KAKEN
In recent years, transition-metal-catalyzed C-H activation has become a key strategy in the field of organic synthesis. Rhodium complexes are widely used as catalysts in a variety of C-H functionalization reactions because of their high reactivity and selectivity. The availability of a number of rhodium complexes in various oxidation states enables diverse reaction patterns to be obtained. Regioselectivity, an important issue in C-H activation chemistry, can be accomplished by using a directing group to assist the reaction. However, to obtain the target functionalized compounds, it is also necessary to use a directing group that can be easily removed. A wide range of directed C-H functionalization reactions catalyzed by rhodium complexes have been reported to date. In this Review, we discuss Rh-catalyzed C-H functionalization reactions that are aided by the use of a removable directing group such as phenol, amine, aldehyde, ketones, ester, acid, sulfonic acid, and N-heteroaromatic derivatives.
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