期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 46, 页码 15128-15132出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201809080
关键词
continuous synthesis; flow chemistry; self-optimization
资金
- Woolf Fisher Trust
- EPSRC [EP/K009494/1, EP/K039520/1, EP/M004120/1]
- H2020-FETOPEN-2016-2017 programme of the European commission [737266-ONE FLOW]
The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.
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