期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 10, 页码 3119-3122出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812701
关键词
C-H fluorination; C-H functionalization; fluorine-18; late-stage fluorination; PET radiochemistry
资金
- NIH [R01EB021155]
- DOE [DE-SC0012484]
A Cu-mediated ortho-C-H radiofluorination of aromatic carboxylic acids that are protected as 8-aminoquinoline benzamides is described. The method uses (KF)-F-18 and is compatible with a wide range of functional groups. The reaction is showcased in the high specific activity automated synthesis of the RAR beta 2 agonist [F-18]AC261066.
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