期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 11, 页码 3373-3377出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812687
关键词
alkynes; benzyl alcohols; potassium tert-butoxide; radicals; alpha-alkylated ketones
资金
- Israel Planning and Budgeting Commission (PBC)
- Azrieli Foundation
- PBC
- Koshland Foundation
- Foreign Postdoctoral Fellowship Program of the Israel Academy of Sciences and Humanities
We report a C-C bond-forming reaction between benzyl alcohols and alkynes in the presence of a catalytic amount of (KOBu)-Bu-t to form alpha-alkylated ketones in which the C=O group is located on the side derived from the alcohol. The reaction proceeds under thermal conditions (125 degrees C) and produces no waste, making the reaction highly atom efficient, environmentally benign, and sustainable. Based on our mechanistic investigations, we propose that the reaction proceeds through radical pathways.
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