期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 5, 页码 1366-1370出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811343
关键词
1,1-diarylalkane; boronic ester; cross-coupling; one-pot; stereospecific
资金
- EPSRC [EP/I038071/1]
- H2020 ERC [670668]
- Principality of Asturias
- EU [ACA17-23]
- Austrian Science Fund (FWF) [J3919-N28]
- Swiss National Science Foundation [P2EZP2 165268]
- BBSRC [BB/F011539/1] Funding Source: UKRI
- EPSRC [EP/I038071/1, EP/K03927X/1, EP/L011999/1] Funding Source: UKRI
- Swiss National Science Foundation (SNF) [P2EZP2_165268] Funding Source: Swiss National Science Foundation (SNF)
- Engineering and Physical Sciences Research Council [EP/K03927X/1] Funding Source: researchfish
The one-pot sequential coupling of benzylamines, boronic esters, and aryl iodides has been investigated. In the presence of an N-activator, the boronate complex formed from an ortho-lithiated benzylamine and a boronic ester undergoes stereospecific 1,2-metalate rearrangement/anti-S(N)2' elimination to form a dearomatized tertiary boronic ester. Treatment with an aryl iodide under palladium catalysis leads to rearomatizing gamma-selective allylic Suzuki-Miyaura cross-coupling to generate 1,1-diarylalkanes. When enantioenriched alpha-substituted benzylamines are employed, the corresponding 1,1-diarylalkanes are formed with high stereospecificity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据