期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 8, 页码 2402-2406出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201813689
关键词
amines; carbonylative reactions; deaminative transformations; Heck reaction; photocatalysis
资金
- National Science Foundation of China [21822103, 21820102003, 21772052, 21772053, 21572074, 21472057]
- Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]
- International Joint Research Center for Intelligent Biosensing Technology and Health
- Natural Science Foundation of Hubei Province [2017AHB047]
The palladium-catalyzed Heck reaction is a well-known, Nobel Prize winning transformation for producing alkenes. Unlike the alkenyl and aryl variants of the Heck reaction, the alkyl-Heck reaction is still underdeveloped owing to the competitive side reactions of alkyl-palladium species. Herein, we describe the development of a deaminative alkyl-Heck-type reaction that proceeds through C-N bond activation by visible-light photoredox catalysis. A variety of aliphatic primary amines were found to be efficient starting materials for this new process, affording the corresponding alkene products in good yields under mild reaction conditions. Moreover, this strategy was successfully applied to deaminative carbonylative alkyl-Heck-type reactions.
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