期刊
ANALYTICAL CHEMISTRY
卷 90, 期 21, 页码 12937-12943出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b03565
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资金
- National Research Foundation of Korea [2012R1A3A2048814, 2016-R1E1A1A02920873, 2018R1D1A1B07043568]
The naphthoimidazolium borane 4 is shown to be a selective probe for HOCl over other reactive oxygen species. Unlike other boronate-reactive oxygen species (ROS) fluorogenic probes that are oxidized by HOCl through a nucleophilic borono-Dakin oxidation mechanism, probe 4 is distinguished by its electrophilic oxidation mechanism involving B-H bond cleavage. Two-photon microscopy experiments in living cells and tissues with the probe 4 demonstrate the monitoring of endogenous HOCl generation and changes in HOCl concentrations generated in the endoplasmic reticulum during oxidative stress situations.
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