期刊
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
卷 199, 期 4, 页码 423-432出版社
AMER THORACIC SOC
DOI: 10.1164/rccm.201810-1931CI
关键词
asthma; asthma exacerbations; virus-induced asthma exacerbations; management of acute asthma
资金
- National Health and Medical Research Council of Australia
- University of Newcastle
- Hunter Medical Research Institute
Acute asthma remains an important medical emergency, the most frequent cause of acute admissions in children and a major source of morbidity for adults with asthma. In all ages with asthma, the presence of exacerbations is an important defining characteristic of asthma severity. In this review, we assess the epidemiology of acute asthma, the triggers of acute exacerbations, and the mechanisms that underlie these exacerbations. We also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that effectively target this. Finally we review current management strategies of the exacerbations themselves.
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