期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 316, 期 2, 页码 E210-E220出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00237.2018
关键词
aberrant crypt foci; hematopoietic stem/progenitor cell; marrow adipose tissue inflammation; mesenchymal stem/stromal cell
资金
- University of Illinois at Urbana-Champaign Research Board
- American College of Sports Medicine
- Natural Sciences and Engineering Research Council
- US Department of Agriculture Cooperative State Research, Education and Extension Service HATCH Project [ILLU-698-923, ILLU-698-369]
Obesity-induced inflammation is associated with increased risk for colorectal cancer (CRC). The role of diet and exercise in modulating increased CRC risk in obesity and the potential role of altered hematopoiesis as a contributor to these effects remain unknown. The purpose of this study was to examine how weight loss induced during CRC induction with or without exercise alters CRC initiation and its relationship to altered hematopoiesis. Mice consumed either a control (CON) or a high-fat diet to induce obesity. All mice were then placed on the control diet during CRC induction with azoxymethane (AOM). Following AOM injection, mice originally on the high-fat diet were randomized into sedentary (HF-SED) or exercise trained (HF-EX) conditions. At euthanasia, body weight and fat mass were similar among all three groups (P < 0.05). Compared with CON and HF-EX, HF-SED developed increased content of preneoplastic lesions (P < 0.05), and HF-SED had significantly increased markers of colon inflammation compared with CON. Compared with both CON and HF-EX, HF-SED had decreased content of short-term hematopoietic stem cells and increased content of common myeloid progenitor cells (both P < 0.05). Similarly, HF-SED had increased bone marrow adiposity compared with CON and HF-EX (P < 0.05), and proteomics analysis revealed an increased marker of bone marrow inflammation in HF-SED compared with CON and HF-EX. Our results suggest that the early removal of a high-fat diet reduces CRC incidence when combined with an exercise training intervention. This reduction in risk was related to lower colon inflammation with anti-inflammatory changes in hematopoiesis induced by exercise.
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