期刊
ALZHEIMERS & DEMENTIA
卷 15, 期 2, 页码 273-281出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2018.08.008
关键词
Physical activity; Cognitive decline; Dementia; Cohort study; Epidemiology
资金
- National Heart, Lung, and Blood Institute [HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C]
- [R01-HL70825]
- [U01 HL096812]
- [HL096814]
- [HL096899]
- [HL096902]
- [HL096917]
Introduction: We tested the hypotheses that higher levels of and persistence of midlife leisure-time physical activity (LTPA) are associated long-term with lower cognitive decline and less incident dementia. Methods: A total of 10,705 participants (mean age: 60 years) had LTPA (no, low, middle, or high) measured in 1987-1989 and 1993-1995. LTPA was assessed in relation to incident dementia and 14-year change in general cognitive performance. Results: Over a median follow-up of 17.4 years, 1063 dementia cases were observed. Compared with no LTPA, high LTPA in midlife was associated with lower incidence of dementia (hazard ratio [95% confidence interval], 0.71 [0.61, 0.86]) and lower declines in general cognitive performance (-0.07 standard deviation difference [-0.12 to -0.04]). These associations were stronger when measured against persistence of midlife LTPA over 6 years. Discussion: LTPA is a readily modifiable factor associated inversely with long-term dementia incidence and cognitive decline. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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