期刊
AGING-US
卷 11, 期 1, 页码 240-248出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101746
关键词
metformin; Bombyx mori; lifespan; energy distribution; AMPK-p53-FoxO pathway
资金
- National Natural Science Foundation of China [31472153, 31830094]
- Hi-Tech Research and Development 863 Program of China [2013AA102507]
- Funds of China Agriculture Research System [CARS-18-ZJ0102]
- Fundamental Research Funds for the Central Universities
Metformin is a hypoglycemic agent used clinically in the treatment of type 2 diabetics. In addition, metformin is being investigated as a potential geroprotector. Here, we investigated the effects of metformin silkworm lifespan and the underlying molecular pathways involved. We found that metformin prolonged the lifespan of the male silkworm without reducing body weight, which suggests metformin can increase lifespan through remodeling of the animal's energy distribution strategy. Consistent with that idea, metformin reduced silk production and thus the energy devoted to that process. Metformin also increased fasting tolerance and levels of the antioxidant glutathione, and also activated an adenosine monophosphate-activated protein kinase-p53-forkhead box class O signaling pathway in silkworm. These results suggest that activity in this pathway may contribute to metformin-induced lifespan extension in silkworm by increasing stress resistance and anti-oxidative capacity while reducing energy output for silk product. The results also show that the silkworm is a potential useful animal model for evaluating the effects of small molecules with potential clinical utility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据