Asymmetric Syntheses of Spirooxindole-dihydroquinazolinones by Cyclization Reactions between N-substituted Anthranilamides and Isatins

A variety of enantioenriched 3-N-substituted spirooxindole-dihydroquinazolinones were synthesized by cyclization reactions involving 2-amino-N-substituted benzamides and isatins catalyzed by SPINOL-CPA catalyst in a highly enantioselective manner with excellent ee values (up to 99%) and good yields (up to 99%). So far, this is the first example to directly access this type of chiral pharmaceutically privileged 3-N-substituted dihydroquinazolinone derivatives with a broad substrate scope.