期刊
ADVANCED MATERIALS
卷 30, 期 50, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201804241
关键词
chirality; drug-resistance; heterodimers; inflammation therapy; polymyxin; upconversion nanoparticles
类别
资金
- National Natural Science Foundation of China [21631005, 21673104, 21522102, 21503095]
- Committee on Animal Welfare of Jiangnan University [20171030b2000430]
Heterodimers of upconversion nanoparticles (UCNPs) and gold yolk-shell nanoparticles are fabricated for the quantification of polymyxin-B-resistant Escherichia coli. They produce two signals, circular dichroism (CD) and upconversion luminescence (UCL). Interestingly, due to the different affinity of polymyxin B for sensitive and resistant strain, as the concentration of polymyxin B increases, the amount of UCNPs in sensitive bacteria increases sharply, increasing the intracellular UCL signal at a low polymyxin B concentration immobilized on the UCNP. The CD intensity is correspondingly reduced as the amount of UCNPs in solution decreased. Meanwhile, for polymyxin-B-resistant strain, the intracellular UCL increases slowly even in a high polymyxin B concentration, and the CD intensity in solution is also enhanced because of the inefficient entering of UCNP. Therefore, based on the concentration of polymyxin B coupled to the UCNPs, the levels of polymyxin-B-resistant bacteria can be detected with dual signals. Importantly, with 980 nm irradiation, both polymyxin-B-sensitive strains and polymyxin-resistant bacteria used to induce infection in mice are detected with UCL imaging in vivo and treated well with photodynamic therapy. This novel dual-mode heterodimer has potential utility for the advanced surveillance and control of drug-resistant bacteria.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据