期刊
ADVANCED MATERIALS
卷 31, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201805875
关键词
bioimaging; biomedical application; biosensing; contrast agents; photoacoustic imaging
类别
资金
- National Natural Science Foundation of China [U1505221, 21635002, 21874024, 21475026]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT15R11]
- Health-Education joint research project of Fujian Province [KJ2016-2-23]
- Minjiang Scholars of Fujian Province
- Intramural Research Program (IRP) of the NIBIB, NIH
Photoacoustic (PA) imaging as a fast-developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light-absorption coefficient of the imaged tissue and the injected PA-imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA-imaging contrast agents are developed to improve the PA-imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold-nanocrystal assembly, transition-metal chalcogenides/MXene-based nanomaterials, carbon-based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA-imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA-imaging contrast agents and their significance in biomedical research is presented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据