期刊
ADVANCED FUNCTIONAL MATERIALS
卷 29, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201806945
关键词
amines; electrophilicity; gold nanoparticles; luminescence; ratiometric imaging
类别
资金
- National Natural Science Foundation of China [21573078, 21506066]
- 1000 Young Talent Program
- Guangdong Natural Science Funds for Distinguished Young Scholars [2016A030306024]
- Guangzhou Technology Project [201804010219]
- China Postdoctoral Science Foundation [2017M622672]
- Fundamental Research Funds for the Central Universities
The surface chemistry of the ultrasmall thiolated gold nanoparticles (AuNPs, < 3.0 nm) plays key roles in both governing the intrinsic emission and establishing interfaces surrounded by various amine-containing biomolecules in the biomedical applications such as imaging, targeting, and diagnostics. However, a fundamental understanding of the surface ligand's role in the stimuli-responsive emissions of AuNPs toward the amine molecules is currently lacking. Here, through investigation of the thiolate surface and exotic amine structures, it is discovered that the nucleophilic amines tend to closely bind the electrophilic gold surface, generating a high-energy stimuli-responsive emission from the low-energy intrinsically emitting AuNPs. Both the intrinsic and stimuli-responsive emissions show a unique amine concentration-dependent ratiometric pattern for quantitative assessments of important biogenic amines in the biological samples. This discovery opens a new pathway to the design of stimuli-responsive AuNPs, and would promote more experimental and theoretical research on the application-driven surface engineering for advanced biological applications.
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