期刊
ADVANCED ENGINEERING MATERIALS
卷 20, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adem.201800329
关键词
bioactive glass; biocomposites; bone implant; in vitro; multiferroics
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi, India [ESC 0103]
- SRF fellowship
Nowadays controlling cellular responses and function of biological molecules is becoming one of the prime areas of focus in biomedical field. In this investigation, an attempt is made to generate in situ charge in bioactive glass (BAG) by incorporating BiFeO3 (BF, a multiferroic material). It is hypothesized that BF in BAG can accelerate cellular activities for rapid tissue healing with externally applied magnetic field due to in situ polarization. BAG composites with different amounts of BF (2 to 15 wt%) are prepared using ball milling followed by pressing and sintering. The composites are characterized in terms of microstructures, constituent phases, magnetic, and electrical properties. Further, in vitro cytotoxicity studies are performed to evaluate the influence of in situ polarization by culturing mouse preosteoblast cells (MC3T3) on BAG-BF composites under different external magnetic field treatments. These in vitro cell-materials interaction studies demonstrate that magnetic field strengths of 200 or 350 mT exposed for 30 min/day can enhance cell viability and proliferation on these composites up to three times. Hence, the authors expect that this investigation will enable further developments to extend the application of multiferroics in bone tissue engineering.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据