期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 138, 期 -, 页码 56-67出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2018.10.017
关键词
Electric field; Electro-responsive drug delivery; Conducting polymers; Electro-responsive hydrogels; Electropermeabilization; Electrochemotherapy; Irreversible electroporation
资金
- RF-METRO-CELL project [ANR-15-ASTR-0017-03]
- research grant Plan Cancer 2014-2019 [NUMEP-PC201615]
- Agence Nationale de la Recherche (ANR) [ANR-15-ASTR-0017] Funding Source: Agence Nationale de la Recherche (ANR)
Electric fields are among physical stimuli that have revolutionized therapy. Occurring endogenously or exogenously, the electric field can be used as a trigger for controlled drug release from electroresponsive drug delivery systems, can stimulate wound healing and cell proliferation, may enhance endocytosis or guide stem cell differentiation. Electric field pulses may be applied to induce cell fusion, can increase the penetration of therapeutic agents into cells, or can be applied as a standalone therapy to ablate tumors. This review describes the main therapeutic trends and overviews the main physical, chemical and biological mechanisms underlying the actions of electric fields. Overall, the electric field can be used in therapeutic approaches in several ways. The electric field can act on drug carriers, cells and tissues. Understanding the multiple effects of this powerful tool will help harnessing its full therapeutic potential in an efficient and safe way. (C) 2018 Published by Elsevier B.V.
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