期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 136, 期 -, 页码 28-48出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2017.12.010
关键词
Bacteria; Antibiotics; Oligonucleotides; Siderophores; Metal nanoparticles; Antimicrobial peptides; Cell-penetrating peptides; Liposomes; Nanomedicines
资金
- European Regional Development Fund (ERDF), through COMPETE2020 - Programa Operacional Competitividade e Internacionalizacao (POCI) [POCI-01-0145-FEDER-006939, UID/EQU/00511/2013]
- FCT - Fundacao para a Ciencia e a Tecnologia
- North Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000005 - LEPABE-2-ECO-INNOVATION]
- DNA mimics Research Project [PIC/IC/82815/2007, NORTE-07-0124-FEDER-000022]
- European Union's Horizon 2020 research and innovation programme [810685]
- Laboratory of General Biochemistry and Physical Pharmacy, Ghent University
- [SFRH/BD/84376/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/84376/2012] Funding Source: FCT
With the dramatic consequences of bacterial resistance to antibiotics, nanomaterials and molecular transporters have started to be investigated as alternative antibacterials or anti-infective carrier systems to improve the internalization of bactericidal drugs. However, the capability of nanomaterials/molecular transporters to overcome the bacterial cell envelope is poorly understood. It is critical to consider the sophisticated architecture of bacterial envelopes and reflect how nanomaterials/molecular transporters can interact with these envelopes, being the major aim of this review. The first part of this manuscript overviews the permeability of bacterial envelopes and how it limits the internalization of common antibiotic and novel oligonucleotide drugs. Subsequently we critically discuss the mechanisms that allow nanomaterials/molecular transporters to overcome the bacterial envelopes, focusing on the most promising ones to this end - siderophores, cyclodextrins, metal nanoparticles, antimicrobial/cell-penetrating peptides and fusogenic liposomes. This review may stimulate drug delivery and microbiology scientists in designing effective nanomaterials/molecular transporters against bacterial infections. (C) 2017 Elsevier B.V. All rights reserved.
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