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Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease
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Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease
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Pre-analytical and analytical factors influencing Alzheimer's disease cerebrospinal fluid biomarker variability
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CLINICA CHIMICA ACTA (2015)
Serum Fragments of Tau for the Differential Diagnosis of Alzheimer's Disease
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CURRENT ALZHEIMER RESEARCH (2015)
YKL-40/CHI3L1 drives inflammation on the road of tumor progression
Stephania Libreros et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2015)
Spreading of pathology in neurodegenerative diseases: a focus on human studies
Johannes Brettschneider et al.
NATURE REVIEWS NEUROSCIENCE (2015)
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Frances K. Wiseman et al.
NATURE REVIEWS NEUROSCIENCE (2015)
Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease
Daniel Alcolea et al.
NEUROBIOLOGY OF AGING (2015)
Vascular dysfunction in the pathogenesis of Alzheimer's disease - A review of endothelium-mediated mechanisms and ensuing vicious circles
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Neurofilament light chain A prognostic biomarker in amyotrophic lateral sclerosis
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Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease
Daniel Alcolea et al.
NEUROLOGY (2015)
Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease
Sebastian Palmqvist et al.
NEUROLOGY (2015)
Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau
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The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer's but Not Parkinson's Disease or Dementia with Lewy Bodies
Malin Wennstrom et al.
PLOS ONE (2015)
TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer's Disease and Schizophrenia
Yoko Mori et al.
PLOS ONE (2015)
Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
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NATURE COMMUNICATIONS (2015)
Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy controls
Hlin Kvartsberg et al.
ALZHEIMERS RESEARCH & THERAPY (2015)
Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort
Maartje I. Kester et al.
ALZHEIMERS RESEARCH & THERAPY (2015)
A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid
Ting Yang et al.
ALZHEIMERS RESEARCH & THERAPY (2015)
Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease
Konstantin Hellwig et al.
ALZHEIMERS RESEARCH & THERAPY (2015)
Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease
Maartje I. Kester et al.
JAMA NEUROLOGY (2015)
Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease
Rawan Tarawneh et al.
JAMA NEUROLOGY (2015)
Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes
Luca Steardo et al.
FRONTIERS IN NEUROSCIENCE (2015)
Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers
Maria Joao Leitao et al.
FRONTIERS IN NEUROLOGY (2015)
Fluid biomarkers in clinical trials of Alzheimer's disease therapeutics
Aaron Ritter et al.
FRONTIERS IN NEUROLOGY (2015)
Cerebrospinal Fluid Aβ40 Improves the Interpretation of Aβ42 Concentration for Diagnosing Alzheimer’s Disease
Aline Dorey et al.
Frontiers in Neurology (2015)
Alzheimer's disease
Colin L. Masters et al.
NATURE REVIEWS DISEASE PRIMERS (2015)
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies
Joery Goossens et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Evaluation of Visinin-Like Protein 1 Concentrations in the Cerebrospinal Fluid of Patients with Mild Cognitive Impairment as a Dynamic Biomarker of Alzheimer's Disease
Barbara Mroczko et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Soluble BACE-1 Activity and sA beta PP beta Concentrations in Alzheimer's Disease and Age-Matched Healthy Control Cerebrospinal Fluid from the Alzheimer's Disease Neuroimaging Initiative-1 Baseline Cohort
Mary J. Savage et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Elevation of the Plasma A beta(40)/A beta(42) Ratio as a Diagnostic Marker of Sporadic Early-Onset Alzheimer's Disease
Hyeong Jun Kim et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Cerebrospinal Fluid Biomarkers Distinguish Postmortem-Confirmed Alzheimer's Disease from Other Dementias and Healthy Controls in the OPTIMA Cohort
Jeffrey L. Seeburger et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer's Disease
Magdalena Groblewska et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Plasma Aβ but Not Tau is Related to Brain PiB Retention in Early Alzheimer's Disease
Kai-Yuan Tzen et al.
ACS CHEMICAL NEUROSCIENCE (2014)
Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease
Thomas A. Bayer et al.
ACTA NEUROPATHOLOGICA (2014)
The future of blood-based biomarkers for Alzheimer's disease
Kim Henriksen et al.
ALZHEIMERS & DEMENTIA (2014)
CSF Aβ1-42 combined with neuroimaging biomarkers in the early detection, diagnosis and prediction of Alzheimer's disease
Simone Lista et al.
ALZHEIMERS & DEMENTIA (2014)
Cerebrospinal fluid BACE1 activity and markers of amyloid precursor protein metabolism and axonal degeneration in Alzheimer's disease
Robert Perneczky et al.
ALZHEIMERS & DEMENTIA (2014)
Increased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels
Sylvie Slaets et al.
ALZHEIMERS & DEMENTIA (2014)
Brain Iron Homeostasis: From Molecular Mechanisms To Clinical Significance and Therapeutic Opportunities
Neena Singh et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020
Harald Hampel et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Increased Expression of TREM2 in Peripheral Blood of Alzheimer's Disease Patients
Nan Hu et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Cerebrospinal Fluid Level of YKL-40 Protein in Preclinical and Prodromal Alzheimer's Disease
Anna Antonell et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions
Fredrik Olsson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014
L. S. Schneider et al.
JOURNAL OF INTERNAL MEDICINE (2014)
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
Robert Vassar et al.
JOURNAL OF NEUROCHEMISTRY (2014)
Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
Takashi Kasai et al.
JOURNAL OF NEUROLOGY (2014)
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation
Marc Suarez-Calvet et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2014)
A Sensitive Aβ Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid
Mary J. Savage et al.
JOURNAL OF NEUROSCIENCE (2014)
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Bruno Dubois et al.
LANCET NEUROLOGY (2014)
SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease
Ann Brinkmalm et al.
MOLECULAR NEURODEGENERATION (2014)
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease
Shichun Tu et al.
MOLECULAR NEURODEGENERATION (2014)
Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
Jing L. Guo et al.
NATURE MEDICINE (2014)
CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival
Tobias Skillback et al.
NEUROLOGY (2014)
The amyloid-β degradation pattern in plasma A possible tool for clinical trials in Alzheimer's disease
Josef Pannee et al.
NEUROSCIENCE LETTERS (2014)
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Rachelle S. Doody et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Modulation of β-amyloid by a single dose of GSK933776 in patients with mild Alzheimer's disease: a phase I study
Thomas Leyhe et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease
Oskar Hansson et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Alpha-synuclein biology in Lewy body diseases
Woojin Scott Kim et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Detection of Misfolded Aβ Oligomers for Sensitive Biochemical Diagnosis of Alzheimer's Disease
Natalia Salvadores et al.
CELL REPORTS (2014)
Improving CSF biomarkers' performance for predicting progression from Mild Cognitive Impairment to Alzheimer's disease by considering different confounding factors: a meta-analysis
Daniel Ferreira et al.
FRONTIERS IN AGING NEUROSCIENCE (2014)
Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases
Emily Feneberg et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2014)
Diagnostic Performance of Cerebrospinal Fluid Total Tau and Phosphorylated Tau in Creutzfeldt-Jakob Disease Results From the Swedish Mortality Registry
Tobias Skillback et al.
JAMA NEUROLOGY (2014)
Increased Levels of Chitotriosidase and YKL-40 in Cerebrospinal Fluid from Patients with Alzheimer's Disease
Christoffer Rosen et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA (2014)
Longitudinal change in CSF Tau and Aβ biomarkers for up to 48 months in ADNI
Jon B. Toledo et al.
ACTA NEUROPATHOLOGICA (2013)
CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease
Jon B. Toledo et al.
ACTA NEUROPATHOLOGICA (2013)
Mild Cognitive Impairment Due to Alzheimer Disease in the Community
Ronald C. Petersen et al.
ANNALS OF NEUROLOGY (2013)
Predicting Alzheimer Disease with β-Amyloid Imaging: Results from the Australian Imaging, Biomarkers, and Lifestyle Study of Ageing
Christopher C. Rowe et al.
ANNALS OF NEUROLOGY (2013)
Amylin Deposition in the Brain: A Second Amyloid in Alzheimer Disease?
Kaleena Jackson et al.
ANNALS OF NEUROLOGY (2013)
Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre
Jon B. Toledo et al.
BRAIN (2013)
Identification of an important potential confound in CSF AD studies: aliquot volume
Jamie Toombs et al.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2013)
The Diagnostic Value of CSF Amyloid-β43 in Differentiation of Dementia Syndromes
Kim A. Bruggink et al.
CURRENT ALZHEIMER RESEARCH (2013)
Heart-type fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer's disease
Liang-Hao Guo et al.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2013)
Cerebrospinal Fluid Aβ1-40 Improves Differential Dementia Diagnosis in Patients with Intermediate P-tau181P Levels
Sylvie Slaets et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
alpha-Synuclein in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment
Ane Korff et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
CSF levels of the neuronal injury biomarker visinin-like protein-1 in Alzheimer's disease and dementia with Lewy bodies
Xinni Luo et al.
JOURNAL OF NEUROCHEMISTRY (2013)
Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling
Daniel Fleck et al.
JOURNAL OF NEUROSCIENCE (2013)
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
Clifford R. Jack et al.
LANCET NEUROLOGY (2013)
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
Victor L. Villemagne et al.
LANCET NEUROLOGY (2013)
Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration
Rahul S. Desikan et al.
MOLECULAR NEURODEGENERATION (2013)
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
Mathias Jucker et al.
NATURE (2013)
Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later
Catherine M. Roe et al.
NEUROLOGY (2013)
GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer's Disease
Carlos Cruchaga et al.
NEURON (2013)
TREM2 Variants in Alzheimer's Disease
Rita Guerreiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer's Disease
Mikko Holtta et al.
PLOS ONE (2013)
Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer's Disease
Jere E. Meredith et al.
PLOS ONE (2013)
The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer's Disease
Elisabeth Kapaki et al.
PLOS ONE (2013)
Blood and plasma-based proteomic biomarker research in Alzheimer's disease
Simone Lista et al.
PROGRESS IN NEUROBIOLOGY (2013)
Biological and methodical challenges of blood-based proteomics in the field of neurological research
Simone Lista et al.
PROGRESS IN NEUROBIOLOGY (2013)
Plasma tau levels in Alzheimer's disease
Henrik Zetterberg et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
A delicate balance: Iron metabolism and diseases of the brain
Dominic Hare et al.
FRONTIERS IN AGING NEUROSCIENCE (2013)
Association of Cerebrospinal Fluid β-Amyloid 1-42, T-tau, P-tau181, and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease
Ju-Hee Kang et al.
JAMA NEUROLOGY (2013)
Safety and biomarker effects of Solanezumab in patients with Alzheimer's disease
Martin Farlow et al.
ALZHEIMERS & DEMENTIA (2012)
Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative
Hugo Vanderstichele et al.
ALZHEIMERS & DEMENTIA (2012)
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Harald Hampel et al.
ALZHEIMERS & DEMENTIA (2012)
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
Peer-Hendrik Kuhn et al.
EMBO JOURNAL (2012)
Increased Protein-Conjugated Acrolein and Amyloid-β40/42 Ratio in Plasma of Patients with Mild Cognitive Impairment and Alzheimer's Disease
Masaaki Waragai et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Risk of Alzheimer's Disease Biological Misdiagnosis Linked to Cerebrospinal Collection Tubes
Armand Perret-Liaudet et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Neurofilaments at a glance
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Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Peter T. Nelson et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2012)
The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
Bin Zhang et al.
JOURNAL OF NEUROSCIENCE (2012)
Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease
Guoxin Wu et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2012)
CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease
R. Tarawneh et al.
NEUROLOGY (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Kelvin C. Luk et al.
SCIENCE (2012)
Phosphorylated α-Synuclein in Parkinson's Disease
Yu Wang et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Examining the mechanisms that link beta-amyloid and alpha-synuclein pathologies
Samuel E. Marsh et al.
ALZHEIMERS RESEARCH & THERAPY (2012)
Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI
Leslie M. Shaw et al.
ACTA NEUROPATHOLOGICA (2011)
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann et al.
ALZHEIMERS & DEMENTIA (2011)
Visinin-like Protein-1: Diagnostic and Prognostic Biomarker in Alzheimer Disease
Rawan Tarawneh et al.
ANNALS OF NEUROLOGY (2011)
Comparison of Analytical Platforms for Cerebrospinal Fluid Measures of β-Amyloid 1-42, Total tau, and P-tau181 for Identifying Alzheimer Disease Amyloid Plaque Pathology
Anne M. Fagan et al.
ARCHIVES OF NEUROLOGY (2011)
Role of amyloid β1-42 and neuroimaging biomarkers in Alzheimer's disease
Simone Lista et al.
BIOMARKERS IN MEDICINE (2011)
CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications
Mingli Liu et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2011)
Qualification opinion of novel methodologies in the predementia stage of Alzheimer's disease: Cerebro-spinal-fluid related biomarkers for drugs affecting amyloid burden - Regulatory considerations by European Medicines Agency focusing in improving benefit/risk in regulatory trials
Maria Isaac et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2011)
Increased CSF-BACE1 Activity Associated with Decreased Hippocampus Volume in Alzheimer's Disease
Michael Ewers et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Human Platelets Tau: A Potential Peripheral Marker for Alzheimer's Disease
Karen Neumann et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Plasma level of chitinase 3-like 1 protein increases in patients with early Alzheimer's disease
Jihye Choi et al.
JOURNAL OF NEUROLOGY (2011)
CSF amyloid β38 as a novel diagnostic marker for dementia with Lewy bodies
Ezra Mulugeta et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2011)
A novel pathway for amyloid precursor protein processing
Erik Portelius et al.
NEUROBIOLOGY OF AGING (2011)
Cerebrospinal Fluid Microglial Markers in Alzheimer's Disease: Elevated Chitotriosidase Activity but Lack of Diagnostic Utility
Niklas Mattsson et al.
NEUROMOLECULAR MEDICINE (2011)
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
William T. Hu et al.
ACTA NEUROPATHOLOGICA (2010)
Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology
Karen A. Lewis et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager et al.
BIOLOGICAL PSYCHIATRY (2010)
YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease
Rebecca Craig-Schapiro et al.
BIOLOGICAL PSYCHIATRY (2010)
Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease
Annika Thorsell et al.
BRAIN RESEARCH (2010)
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
Irina Kuperstein et al.
EMBO JOURNAL (2010)
Pyroglutamate-Aβ: Role in the natural history of Alzheimer's disease
Adam P. Gunn et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)
Neurogranin, a Link Between Calcium/Calmodulin and Protein Kinase C Signaling in Synaptic Plasticity
F. Javier Diez-Guerra
IUBMB LIFE (2010)
Biomarkers as Predictors for Conversion from Mild Cognitive Impairment to Alzheimer-Type Dementia: Implications for Trial Design
Ineke A. van Rossum et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
BACE1 Activity in Cerebrospinal Fluid and Its Relation to Markers of AD Pathology
Sandra D. Mulder et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Differential levels of α-synuclein, β-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease
Kensaku Kasuga et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2010)
Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy
Kurt R. Brunden et al.
JOURNAL OF NEUROSCIENCE (2010)
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
Harald Hampel et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
TAR DNA-binding protein 43 in neurodegenerative disease
Alice S. Chen-Plotkin et al.
NATURE REVIEWS NEUROLOGY (2010)
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Kaj Blennow et al.
NATURE REVIEWS NEUROLOGY (2010)
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease
T. Tokuda et al.
NEUROLOGY (2010)
Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease
Min Shi et al.
NEUROSCIENCE LETTERS (2010)
Cerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative Subjects
Leslie M. Shaw et al.
ANNALS OF NEUROLOGY (2009)
Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain
Tero Tapiola et al.
ARCHIVES OF NEUROLOGY (2009)
Beta Amyloid in Alzheimer's Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid
Timo Grimmer et al.
BIOLOGICAL PSYCHIATRY (2009)
Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease
Anne M. Fagan et al.
EMBO MOLECULAR MEDICINE (2009)
EVOLUTION OF Aβ42 AND Aβ40 LEVELS AND Aβ42/Aβ40 RATIO IN PLASMA DURING PROGRESSION OF ALZHEIMER'S DISEASE: A MULTICENTER ASSESSMENT
K. Blennow et al.
JOURNAL OF NUTRITION HEALTH & AGING (2009)
Relationships between biomarkers in aging and dementia
W. J. Jagust et al.
NEUROLOGY (2009)
Longitudinal Study of CSF Biomarkers in Patients with Alzheimer's Disease
Peder Buchhave et al.
PLOS ONE (2009)
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration
Penelope Foulds et al.
ACTA NEUROPATHOLOGICA (2008)
Core candidate neurochemical and imaging biomarkers of Alzheimer's disease
Harald Hampel et al.
ALZHEIMERS & DEMENTIA (2008)
Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease
Henrik Zetterberg et al.
ARCHIVES OF NEUROLOGY (2008)
Increased CSF-BACE 1 activity is associated with ApoE-ε4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
Michael Ewers et al.
BRAIN (2008)
Decrease in age-adjusted cerebrospinal fluid β-secretase activity in Alzheimer's subjects
Guoxin Wu et al.
CLINICAL BIOCHEMISTRY (2008)
The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients
Jin-Moo Lee et al.
CLINICAL CHEMISTRY (2008)
Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
Brit Mollenhauer et al.
EXPERIMENTAL NEUROLOGY (2008)
Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype
K. A. Josephs et al.
NEUROLOGY (2008)
Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals
E. C. Downes et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2008)
CSF tau/Aβ42 ratio for increased risk of mild cognitive impairment -: A follow-up study
G. Li et al.
NEUROLOGY (2007)
Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-β in cultured cortical neurons:: evidence that tau phosphorylation is the limiting factor in amyloid-β-induced cell death
Julia Leschik et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Longitudinal stability of CSF biomarkers in Alzheimer's disease
Kaj Blennow et al.
NEUROSCIENCE LETTERS (2007)
Amyloid β peptide ratio 42/40 but not Aβ42 correlates with phospho-Tau in patients with low- and high-CSF Aβ40 load
Jens Wiltfang et al.
JOURNAL OF NEUROCHEMISTRY (2007)
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
Catalina Amador-Ortiz et al.
ANNALS OF NEUROLOGY (2007)
Cerebrospinal fluid tau/β-amyloid42 ratio as a prediction of cognitive decline in nondemented older adults
Anne M. Fagan et al.
ARCHIVES OF NEUROLOGY (2007)
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
Yasumasa Yoshiyama et al.
NEURON (2007)
Aβ40 inhibits amyloid deposition in vivo
Jungsu Kim et al.
JOURNAL OF NEUROSCIENCE (2007)
IP-10 serum levels are not increased in mild cognitive impairment and Alzheimer's disease
D. Galimberti et al.
EUROPEAN JOURNAL OF NEUROLOGY (2007)
A systematic review and meta-analysis of CSF neurofilament protein levels as biomarkers in dementia
A. Petzold et al.
NEURODEGENERATIVE DISEASES (2007)
Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: Marker candidates for dementia with Lewy bodies
Brit Mollenhauer et al.
NEURODEGENERATIVE DISEASES (2007)
Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years
Henrik Zetterberg et al.
JOURNAL OF ALZHEIMERS DISEASE (2007)
CSF neurofilaments in frontotemporal dementia compared with early onset Alzheimer's disease and controls
Yolande A. L. Pijnenburg et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2007)
Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment
Zhenyu Zhong et al.
ARCHIVES OF GENERAL PSYCHIATRY (2007)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
Stephen W. Scheff et al.
NEUROBIOLOGY OF AGING (2006)
The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy
P. H. Lee et al.
JOURNAL OF NEURAL TRANSMISSION (2006)
Identification of novel brain biomarkers
Omar F. Laterza et al.
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Plasma Aβ1-40 and Aβ1-42 and the risk of dementia:: a prospective case-cohort study
Marieke van Oijen et al.
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Determination of β-amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation-mass spectrometry
E Portelius et al.
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Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease
D Galimberti et al.
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Lewy body pathology in familial Alzheimer disease - Evidence for disease- and mutation-specific pathologic phenotype
JB Leverenz et al.
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Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
O Hansson et al.
LANCET NEUROLOGY (2006)
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans
AM Fagan et al.
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Aβ42 is essential for parenchymal and vascular amyloid deposition in mice
E McGowan et al.
NEURON (2005)
Biological markers for therapeutic trials in Alzheimer's disease - Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease
RA Frank et al.
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Initiation and synergistic fibrillization of tau and alpha-synuclein
BI Giasson et al.
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CSF Aβ 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
D Strozyk et al.
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Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias
M Riemenschneider et al.
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Neurofilament protein in cerebrospinal fluid:: A marker of white matter changes
M Sjögren et al.
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Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
E Masliah et al.
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VMY Lee et al.
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Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains
CI Sze et al.
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Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease
PD Mehta et al.
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