期刊
ACS NANO
卷 12, 期 12, 页码 12096-12108出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b05292
关键词
cell-membrane immunotherapy; NK cell membranes; M1 macrophages; photodynamic therapy; antitumor immunity
类别
资金
- Key International S&T Cooperation Project [2015DFH50230]
- National Natural Science Foundation of China [31571013, 81671758, 51502333, 81501580]
- Guangdong Natural Science Foundation of Research Team [2016A030312006]
- Shenzhen Science and Technology Program [JSGG20160331185422390, JCYJ20160429191503002, JCYJ20170818162522440, JCYJ20170818154843625]
Developing effective immunotherapies with low toxicity and high tumor specificity is the ultimate goal in the battle against cancer. Here, we reported a cell-membrane immunotherapy strategy that was able to eliminate primary tumors and inhibited distant tumors by using natural killer (NK) cell membrane cloaked photosensitizer 4,4',4 '',4'-(porphine-5,10,15,20-tetrayl) tetrakis (benzoic acid) (TCPP)-loaded nanoparticles (NK-NPs). The proteomic profiling of NK cell membranes was performed through shotgun proteomics, and we found that NK cell membranes enabled the NK-NPs to target tumors and could induce or enhance pro-inflammatory M1-macrophages polarization to produce antitumor immunity. The TCPP loaded in NK-NPs could induce cancer cell death through photodynamic therapy and consequently enhanced the antitumor immunity efficiency of the NK cell membranes. The results confirmed that NK-NPs selectively accumulated in the tumor and were able to eliminate primary tumor growth and produce an abscopal effect to inhibit distant tumors. This cell-membrane immunotherapeutic approach offers a strategy for tumor immunotherapy.
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