4.6 Article

Local μ-Opioid Receptor Antagonism Blunts Evoked Phasic Dopamine Release in the Nucleus Accumbens of Rats

期刊

ACS CHEMICAL NEUROSCIENCE
卷 10, 期 4, 页码 1935-1940

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.8b00437

关键词

mu-opioid receptor; dopamine; accumbens; phasic; electrochemistry; local infusion

资金

  1. Klarman Family Foundation
  2. UNC Bowles Center for Alcohol Studies
  3. Summer Undergraduate Research Fellowship from the Office for Undergraduate Research at the University of North Carolina at Chapel Hill

向作者/读者索取更多资源

mu-opioid receptors (MORs) in the nucleus accumbens (NAc) can regulate reward related behaviors that are dependent on mesolimbic dopamine, but the precise mechanism of this MOR regulation is unknown. We hypothesized that MORs within the NAc core regulate dopamine release. Specifically, we infused the MOR antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) into the NAc core while dopamine release was evoked by electrical stimulation of the ventral tegmental area and measured by fast-scan cyclic voltammetry. We report that CTAP dose dependently inhibited evoked dopamine release, with full blockade achieved with the 8 mu g infusion. In contrast, evoked dopamine release increased after nomifensine infusion and was unchanged after vehicle infusion. These findings demonstrate profound local control of dopamine release by MORs within the NAc core, which has implications for regulation of reward processing.

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