期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 5, 页码 4809-4819出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b18981
关键词
microneedle; biosensing; nanostructure; dissolvable polymer coating; transdermal biosensing
资金
- National Natural Science Foundation of China [61771498, 31530023, 81671379, 51705543]
- Youth 1000 Talents Program of China [76120-18821104]
- Youth Teacher Training Program of Sun Yat-Sen University [18lgpy18, 18lgpy21]
- Science and Technology Program of Guangzhou, China [201803010097]
- Guangdong Province Science and Technology Plan Foundation [2016A020215056, 2017A020215085, 2017B090917001]
Real-time transdermal biosensing provides a direct route to quantify biomarkers or physiological signals of local tissues. Although microneedles (MNs) present a mini-invasive transdermal technique, integration of MNs with advanced nanostructures to enhance sensing functionalities has rarely been achieved. This is largely due to the fact that nanostructures present on MNs surface could be easily destructed due to friction during skin insertion. In this work, we reported a dissolvable polymer-coating technique to protect nanostructures-integrated MNs from mechanical destruction during MNs insertion. After penetration into the skin, the polymer could readily dissolve by interstitial fluids so that the superficial nanostructures on MNs could be re exposed for sensing purpose. To demonstrate this technique, metallic and resin MNs decorated with vertical ZnO nanowires (vNWs) were employed as an example. Dissolvable poly(vinyl pyrrolidone) was spray-coated on the vNWMNs surface as a protective layer, which effectively protected the superficial ZnO NWs when MNs penetrated the skin. Transdermal biosensing of H2O, biomarker in skin tissue using the polymer-protecting MNs sensor was demonstrated both ex vivo and in vivo. The results indicated that polymer coating successfully preserved the sensing functionalities of the MNs sensor after inserting into the skin, whereas the sensitivity of the MN sensor without a coating protection was significantly compromised by 3-folds. This work provided unique opportunities of protecting functional nanomodulus on MNs surface for minimally invasive transdermal biosensing.
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