期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 4, 页码 3763-3770出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b20594
关键词
curcumin; ischemia/reperfusion injury; blood brain barrier; antioxidation; anti-inflammation
资金
- National Natural Science Foundation of China [81760417, 81660230, 81871031]
- Science and Technology Program of Jiangxi, China [2016ACB21019, 2018ACB20020]
Oxidative stress and inflammation are two important pathophysiological mechanisms that arouse neuronal apoptosis and cerebral damage after ischemia/reperfusion (I/R) injury. Here, we hypothesized that curcumin-encapsulated nanoparticles (NPcurcumin) could reduce oxidative stress and inflammation in the ischemic penumbra via protecting the blood-brain barrier (BBB) and inhibiting M1-microglial activation. Under oxidative stress conditions in vitro, we found that NPcurcumin protected microvascular endothelial cells against oxidative stress and reduced BBB permeability. In vivo, NPcurcumin could cross the BBB and accumulate in the ischemic penumbra. At 3 d after I/R injury, NPcurcumin inhibited the increase in MMP-9, attenuated the decrease in occludin and zona occluden-1, and maintained BBB integrity. NPcurcumin effectively reduced the number of activated M1 microglia and weakened the increase in TNF-alpha and IL-beta. Furthermore, NPcurcumin also reduced the infarct size and improved function recovery.
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