期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 49, 页码 41917-41923出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b12351
关键词
nanoparticles; dual functionalization; corona free nanoparticles; hemolysis; cytotoxicity
资金
- FAPESP [2014/22322-2, 2015/25406-5, 2013/22429-9, BEPE 2015/21918-1]
- LNLS
- LNNano
- CNPq [309107/2014-8]
- NIH [GM077173, EB022641]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [15/25406-5] Funding Source: FAPESP
Protein coronas form on the surfaces of nanomaterials in biological fluids. This layer of proteins affects the properties of nanomaterials, altering their behavior and masking engineered functionality. The use of nonfouling moieties reduces or prevents corona formation; however, these ligands typically complicate functionalization. We present here a surface modification strategy for silica nanoparticles using specific molar ratios of zwitterionic and amine moieties. Through proper balance of ligands, we were able to generate particles that featured reactive handles, while retaining nonfouling properties, high hemocompatibility, and low cytotoxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据