Fabrication of Supramolecular Bioactive Surfaces via β-Cyclodextrin-Based Host-Guest Interactions

Supramolecular host-guest interactions provide a facile and versatile basis for the construction of sophisticated structures and functional assemblies through specific molecular recognition of host and guest molecules to form inclusion complexes. In recent years, these interactions have been exploited as a means of attaching bioactive molecules and polymers to solid substrates for the fabrication of bioactive surfaces. Using a common host molecule, beta-cyclodextrin (beta-CD), and various guest molecules as molecular building blocks, we fabricated several types of bioactive surfaces with multifunctionality and/or function switchability via host-guest interactions. Other groups have also taken this approach, and several intelligent designs have been developed. The results of these investigations indicate that, compared to the more common covalent bonding-based methods for attachment of bioactive ligands, host guest based methods are simple, more broadly (universally) applicable, and allow convenient renewal of bioactivity. In this Spotlight on Applications, we review and summarize recent developments in the fabrication of supramolecular bioactive surfaces via beta-CD-based host-guest interactions. The main focus is on the work from our laboratory, but highlights on work from other groups are included. Applications of the materials are also emphasized. These surfaces can be categorized into three types based on: (i) self-assembled monolayers, (ii) polymer brushes, and (iii) multilayered films. The host-guest strategy can be extended from material surfaces to living cell surfaces, and work along these lines is also reviewed. Finally, a brief perspective on the developments of supramolecular bioactive surfaces in the future is presented.